The region surrounding Johannesburg was originally inhabited by San tribes. By the 13th century, groups of Bantu-speaking people started moving southwards from central Africa and encroached on the indigenous San population. By the mid 18th century, the broader region was densely settled by various Sotho-Tswana communities (one linguistic branch of Bantu-speakers), whose villages, towns, chiefdoms and kingdoms stretched from what is now Botswana in the west, to present day Lesotho in the south, to the present day Pedi areas of the northern Transvaal.

More specifically, the stone-walled ruins of Sotho-Tswana towns and villages are scattered around the parts of the former Transvaal in which Johannesburg is situated. The Sotho-Tswana practiced farming, raised cattle, sheep and goats, and extensively mined and smelted copper, iron and tin. Moreover, from the early 1960s until his retirement, Professor Revil Mason, of the University of the Witwatersrand, explored and documented many Late Iron Age archeological sites throughout the Johannesburg area, dating from between the 12th century and 18th century, and many of these sites contained the ruins of Sotho-Tswana mines and iron smelting furnaces, suggesting that the area was being exploited for its mineral wealth before the arrival of Europeans or the discovery of gold. The most prominent site within Johannesburg is Melville Koppies, which contains an iron smelting furnace.

Many Sotho-Tswana towns and villages in the areas around Johannesburg were destroyed and their people driven away during the wars emanating from Zululand during the late 18th and early 19th centuries (the mfecane or difaqane wars), and as a result, an offshoot of the Zulu kingdom, the Ndebele (often referred to by the name the local Sotho-Tswana gave them, the Matebele), set up a kingdom to the northwest of Johannesburg around modern day Hartebeestpoort and Rustenburg, and historians believe that the Matebele kingdom dominated the Johannesburg area.

The Dutch speaking Voortrekkers arrived in the early 19th century, driving away the Matebele with the help of Sotho-Tswana allies, establishing settlements around Rustenburg and Pretoria in the early 1830s, and claiming sovereignty over what would become Johannesburg as part of the South African Republic or Transvaal Republic. Gold was discovered in the 1880s and triggered the gold rush. Gold was initially discovered some 400 km to the east of present-day Johannesburg, in Barberton. Gold prospectors soon discovered that there were even richer gold reefs in the Witwatersrand. Gold was discovered at Langlaagte, Johannesburg in 1886. Johannesburg was a dusty settlement some 55 km from the Transvaal Republic capital which was Pretoria. The town was much the same as any small prospecting settlement, but, as word spread, people flocked to the area from all other regions of the country, as well as from North America, the United Kingdom and Europe.

As the value of control of the land increased, tensions developed between the Boer government in Pretoria and the British, culminating in the Jameson Raid that ended in fiasco at Doornkop in January 1896 and the Second Boer War (1899–1902) that saw British forces under Lord Roberts occupy the city on 30 May 1900 after a series of battles to the south of its then-limits. Fighting took place at the Gatsrand Pass (near Zakariyya Park) on 27 May, north of Vanwyksrust—today's Nancefield, Eldorado Park and Naturena—the next day, culminating in a mass infantry attack on what is now the waterworks ridge in Chiawelo and Senaoane on 29 May.[citation needed] Controversy surrounds the origin of the name, as there were any number of people with the name "Johannes" who were involved in the early history of the city. The principal clerk attached to the office of the surveyor-general, Johannes Rissik, Christiaan Johannes Joubert, member of the Volksraad and the Republic's chief of mining, Paul Kruger, President of the South African Republic. Rissik and Joubert were members of a delegation sent to England to attain mining rights for the area. Joubert had a park in the city named after him and Rissik street is today a main street where the (historically important and dilapidated,[11] since burnt out) Post Office and City Hall are located.

Major building developments took place in the 1930s, after South Africa went off the gold standard. In the late 1940s and early 1950s, Hillbrow went high-rise. In the 1950s and early 1960s, the apartheid government constructed the massive agglomeration of townships that became known as Soweto (SOuth WEstern TOwnships). New freeways encouraged massive suburban sprawl to the north of the city. In the late 1960s and early 1970s, tower blocks (including the Carlton Centre and the Southern Life Centre) filled the skyline of the central business district. The central area of the city underwent something of a decline in the 1980s and 1990s, due to crime and when property speculators directed large amounts of capital into suburban shopping malls, decentralised office parks, and entertainment centres. Sandton City was opened in 1973, followed by Rosebank Mall in 1976, and Eastgate in 1979.

On May 12, 2008 a series of riots started in the township of Alexandra, in the north-eastern part of Johannesburg, when locals attacked migrants from Mozambique, Malawi and Zimbabwe, killing two people and injuring 40 others. These riots sparked the xenophobic attacks of 2008. Soccer City in Johannesburg hosted the 2010 FIFA World Cup final.

Coordinates: 26,1216 28,244